Next-Generation Bioreactor System

CRISPR-Modified Chicken PGCs for High-Yield Recombinant Protein Production

Revolutionizing protein production with avian biotechnology - producing valuable biologics at a fraction of current costs

Explore the Opportunity

Built on CRISPR-Modified Chicken PGCs

Primordial Germ Cells are the foundation of our innovative bioreactor system

Primordial Germ Cells (PGCs)

Primary undifferentiated stem cells that differentiate towards gametes: spermatozoa or oocytes. PGCs serve as tools for storing high-quality genetic resources, wildlife conservation, and expression of recombinant proteins.

Gene Editing Capability

CRISPR technology enables precise genetic modifications in chicken PGCs, allowing targeted insertion of genes for valuable recombinant protein expression directly in egg production.

Scalable Bioreactor

Each gene-edited chicken becomes a living bioreactor, producing designer eggs containing high-quality recombinant proteins. Simple, efficient, and infinitely scalable.

Massive Market Opportunity

The global recombinant protein market is experiencing explosive growth

$2.4B+

Global Market Size

14%

Annual Growth Rate

90%

Cost Reduction Potential

∞

Production Scalability

Our Technology Platform

Three integrated approaches deliver reliable, scalable protein production

CRISPR Delivery Platform

We identify target DNA sequences and design plasmids carrying Cas9 and guide RNA. Delivery through viral vectors, transfection, or direct microinjection produces gene-edited chicken cell lines with precision.

Knock-in Generation

CRISPR makes precise cuts in the bird's DNA while providing matching donor templates. The cell naturally repairs by copying new genes into its genome, enabling accurate and stable transgene expression.

Bioreactor Production

Edited germ cells are placed into embryos, growing chickens that lay eggs containing desired recombinant proteins. Each egg becomes a simple, scalable production unit for valuable biologics.

Proven Production Results

Real-world validation of our technology platform

Wild-Type vs. Knock-In Egg Production

Reference: Oishi, I., Yoshii, K., Miyahara, D. et al. Efficient production of human interferon beta in the white of eggs from ovalbumin gene-targeted hens. Sci Rep 8, 10203 (2018).

Wild-Type (WT) Eggs

Normal size and appearance
Clear, uniform albumen composition
Standard viscosity throughout
Typical egg-white structure

Knock-In (KI) Eggs

Reduced size due to protein loading
Visibly altered egg-white structure
Watery regions with gelatinous clumps
High recombinant protein content
Modified viscosity from protein expression

Key Insight: The altered albumen structure in KI eggs confirms successful high-level recombinant protein secretion in the oviduct, validating our approach for commercial-scale production.